Page 15 - MEGIN Book Of Abstracts - 2022

Aging

Spatiotemporal Oscillatory Patterns During window, MCI showed reduced power in temporo-
Working Memory Maintenance in Mild Cognitive posterior regions relative to controls (p = 3 × 10-03)
Impairment and Subjective Cognitive Decline and SCD (p = 0.02). Our results may suggest that these
(2020) alterations would re!ect that memory-related networks
are damaged.
Serrano, N; López-Sanz, D; Bruña, R; Garcés, P; Rodríguez-
Rojo, I C; Marcos, A; Crespo, D Prada; Maestú, F Keywords: Alzheimer’s disease (AD), Induced oscillatory
activity, magnetoencephalography (MEG), mild cognitive
Laboratory of Cognitive and Computational Neuroscience impairment (MCI), subjective cognitive decline (SCD),
(UCM-UPM), Center for Biomedical Technology (CTB), Pozuelo working memory (WM)
de Alarcón, Madrid 28223, Spain; CIBER's Bioengineering,
Biomaterials and Nanomedicine (CIBER-BBN), Institute of International journal of neural systems (2020), Vol. 30, No.
Health Carlos III, Madrid, Spain; Neurology Department, San 1 (31522594)
Carlos Clinical Hospital, Madrid, Spain; Centro de Prevención
del Deterioro Cognitivo del Ayuntamiento, de Madrid Madrid,
Spain The impact of age and sex on the oscillatory
dynamics of visuospatial processing (2019)
ABSTRACT Working memory (WM) is a crucial cogni-
tive process and its disruption is among the earliest Wiesman, Alex I; Wilson, Tony W
symptoms of Alzheimer's disease. While alterations
of the neuronal processes underlying WM have been Department of Neurological Sciences, University of Nebraska
evidenced in mild cognitive impairment (MCI), scarce Medical Center, Omaha, NE, USA; Center for Magnetoen-
literature is available in subjective cognitive decline cephalography, UNMC, Omaha, NE, USA; Department of
(SCD). We used magnetoencephalography during a Neurological Sciences, University of Nebraska Medical Center,
WM task performed by MCI (n = 45), SCD (n = 49) and Omaha, NE, USA; Center for Magnetoencephalography,
healthy elders (n = 49) to examine group di#erences UNMC, Omaha, NE, USA. Electronic address: twwilson@
during the maintenance period (0-4000ms). Data were unmc.edu
analyzed using time-frequency analysis and signi"cant
oscillatory di#erences were localized at the source ABSTRACT The ability to dynamically allocate neural
level. Our results indicated signi"cant di#erences resources within the visual space is supported by a
between groups, mainly during the early maintenance number of spectrally-speci"c oscillatory responses,
(250-1250ms) in the theta, alpha and beta bands and in and such visuospatial processing has been found to
the late maintenance (2750-3750ms) in the theta band. decline moderately with age and di#er by sex. How-
MCI showed lower local synchronization in fronto-tem- ever, the direct e#ects of age and sex on these oscil-
poral cortical regions in the early theta-alpha window latory dynamics remains poorly understood. Using
relative to controls (p = 2 × 10-03) and SCD (p = 4 × 10- magnetoencephalography (MEG), structural magnetic
03), and in the late theta window relative to controls (p resonance imaging, and advanced source reconstruc-
= 1 × 1003) and SCD (p = 0.01). Early theta-alpha power tion and statistical methods, we investigated the
was signi"cantly correlated with memory scores (rho = impact of aging and sex on behavioral performance
0.24,p = 0.02) and late theta power was correlated with and the underlying neural dynamics during visuospa-
task performance (rho = 0.24,p = 0.03) and functional tial processing. In a large sample spanning a broad age
activity scores (rho = -0.23,p = 0.02). In the early beta range, we "nd that a number of prototypical attention

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